No harm reported at 200mg, and a test skewed at 10mg
No upper limit for biotin has been set, for lack of data, and no toxicity has been seen up to 200mg by mouth. A 10mg daily dose was already enough to disturb a troponin test.
What the study found
No toxicity to 200mg of biotin, and a blood test broken far below
No upper limit for biotin has been set, because there were not enough data on adverse effects to set one, and no toxicity has been seen at up to 200mg by mouth. That is a statement about the body. A 10mg daily dose was already enough to disturb a troponin test.
The caveat · No harm reported is not proven safe
Absence of reported harm is not demonstrated safety; it is what an unset upper limit actually means, and the panel that could not set one said so. That panel was writing in 2012 about intravenous nutrition products, before the interference literature existed, and is silent on blood tests.