SubEx
Caffeine·Support heart and blood flow·finding 16 of 18
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★☆☆Contested — the evidence disagrees with itself, or the finding carries a caution. A caution or conflict always shows one star, however strong the sources are.

Physical & body · mixed evidence · contested

Your blood pressure may get used to daily caffeine within three weeks

In one trial of 11 adults taking caffeine daily, its blood-pressure rise had faded to near zero by day 20. The nervousness and poor sleep had not.

What the study found

In 11 adults, daily caffeine's blood-pressure rise had faded by day 20

Eleven healthy adults took 3 mg of caffeine per kg of body weight daily for 20 days, and a placebo for 20. Over the first eight days systolic pressure ran 7.8% higher; by day 20 the gap was near zero, while nervousness, poor sleep and extra urination carried on.

The caveat · Too few to say how fully it fades

Eleven people give only a rough picture of when the rise fades and how completely. One moderate dose was tested, about 210 mg for a 70 kg adult, not the range people drink.

What we don't know

In one small trial, daily caffeine's blood-pressure rise faded to near zero within three weeks; pooled trials found about 2 mmHg that was larger in longer trials. Whether the body adapts fully or only partly is unsettled.