Nausea is common and rarely the reason people stop
In the adult trials behind the US label, nausea reached 44% against 16% on placebo and vomiting 24% against 6%. Just 1.8% quit the drug over nausea.
What the study found
Nausea hit 44% on the drug and 16% on placebo
Almost everyone hears about the nausea; far fewer hear how few people it stopped. In the adult trials behind the US label, vomiting ran 24% against 6% on placebo and constipation 24% against 11%, in 2,116 treated adults. Only 1.8% of them quit the drug over nausea, against 0.2% on placebo.
The caveat · Trial volunteers, not everyday users
A label is the manufacturer's own trial programme summarised by the regulator, not an independent analysis, and trial populations exclude many people who take the drug in practice. The label carries a separate table for children with different figures. The copy read here is dated March 2024 and the agency marks it as possibly not the current version.