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★★★Well replicated — this finding’s sources average out to meta-analyses, systematic reviews or high-powered trials.
In the trial the whole category was built on, weight fell 14.9%
In 1,961 adults with obesity and no diabetes, 68 weeks of once-weekly 2.4 mg took mean body weight down 14.9%, against 2.4% on placebo.
What the study found
Sixty-eight weeks on semaglutide took off 14.9% of body weight
This is the trial the whole category was built on. In 1,961 adults with obesity and no diabetes, once-weekly 2.4mg semaglutide moved mean body weight down 14.9% against 2.4% on placebo, and 86.4% of them lost at least 5% of their weight, against 31.5% on placebo.
The caveat · Mostly women, mostly white
Novo Nordisk funded the trial and the drug is theirs. The cohort was largely female and largely white, so it says less about everyone else. Sixty-eight weeks is what was measured, and nothing here describes what happens after the last injection.