In a bigger body, the same vitamin reads as a lower level
Modelling 686 unsupplemented adults, blood levels tracked body weight so closely that the obesity-related difference vanished once weight was accounted for.
What the study found
Low vitamin D in obesity is dilution, not fat trapping it
Modelling 686 unsupplemented adults, blood 25-hydroxyvitamin D tracked body weight so closely that the obesity-related difference vanished once weight was accounted for. The same vitamin spread through a larger body reads as a lower level, so the dose should scale with body size.
The caveat · A curve fit, not a mechanism test
This is a snapshot of two existing groups at one research unit, so it shows which mathematical curve fits best rather than testing the mechanism directly. Ruling out fat trapping the vitamin rests on that better fit, which is suggestive rather than conclusive. The advice to scale a dose by body weight follows from the model and was not itself tested here.