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Settled ground

More melatonin did not mean more sleep, and 30 minutes was late

Across 26 trials the sleep effect stopped climbing at around 4mg a day, and shifting it to about 3 hours before bed improved both how fast people fell asleep and how long they slept.

Melatonin

Melatonin is usually bought at whatever dose the bottle suggests and swallowed half an hour before bed. Across 26 trials the effect stopped climbing near 4mg a day, and shifting the dose to roughly 3 hours before bed left people falling asleep faster and sleeping longer. That pairing is the peak of a curve drawn across differing trials, never run head to head against the usual timing. The number on the bottle was never the variable that mattered most.

The findings behind this

SleepMelatonin's effect peaked near 4 mg taken three hours before bed

Across 26 trials the sleep effect peaked near 4 mg a day rather than climbing with dose, and moving it to about 3 hours before bed improved falling asleep and sleep length.

★★★Well replicated — this finding’s sources average out to meta-analyses, systematic reviews or high-powered trials.That pairing is the peak of a curve drawn across many different trials, not a regimen any single trial actually ran. Nobody has yet put it head to head against the usual 30-minutes-before dose, which is the comparison that would settle it. The pooled trials span 1987 to 2020 and differ widely in whom they enrolled.Click to keep this openSleep betterMelatonin

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