SubEx
Diphenhydramine·Sleep better·finding 23 of 26
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★☆☆Contested — the evidence disagrees with itself, or the finding carries a caution. A caution or conflict always shows one star, however strong the sources are.

Mental & cognitive · decreases · contested

One trial found speed control still worse the morning after

Fifty-nine volunteers took a sleep-aid dose at 11.30pm and drove 100 km in a simulator 6.5 hours later. Lane position, the trial's own main measure, did not move.

What the study found

The next-morning evidence is one trial and one measure

Fifty-nine volunteers took a sleep-aid dose at 11.30pm and were woken 6.5 hours later to drive 100 km in a simulator. Speed control was significantly worse than after placebo. Lane position, the trial's own primary measure, did not, so the effect is real here and narrower than it sounds.

The caveat · Designed by a competitor's maker

The dose, 76 mg of the citrate salt, is an ordinary amount in an unfamiliar unit, matching the 50 mg of hydrochloride a sleep aid delivers. Under the prespecified testing plan, the remaining comparisons were non-significant or ineligible to test. A competing product's maker designed and part-authored it.

What we don't know

The dose, 76 mg of the citrate salt, is an ordinary amount in an unfamiliar unit, matching the 50 mg of hydrochloride a sleep aid delivers. Under the prespecified testing plan, the remaining comparisons were non-significant or ineligible to test. A competing product's maker designed and part-authored it.