★★★Well replicated — this finding’s sources average out to meta-analyses, systematic reviews or high-powered trials.
In a real ovary the ratio is 100 to 1, or 0.2 to 1 with PCOS
The 40 to 1 claim rests on a mouse study. Measured in the ovary, the ratio is 100 to 1 in women without polycystic ovary syndrome, or PCOS, and 0.2 to 1 in women who have it.
What the study found
The 40:1 ratio is not the one measured in a human ovary
The claim that 40 to 1 is physiological rests on a mouse study in which it reversed features of the condition. Measured in the ovary, the ratio is 100 to 1 in women without polycystic ovary syndrome, or PCOS, and 0.2 to 1 in women who have it.
The caveat · Cited as background, not a study
These figures are reported as background inside a guideline evidence review, not measured by a study designed for the question. That same review rated every comparison of different inositol ratios at the lowest certainty its framework offers.