Higher doses raised blood NAD, and the trial measured no benefit
At 100, 300 and 1,000 mg a day, whole blood NAD rose 22, 51 and 142 percent within two weeks and held there for eight. The trial measured no benefit at all.
What the study found
The one clean dose-response curve here measures absorption
Nicotinamide riboside at 100, 300 and 1,000 mg a day raised whole-blood nicotinamide adenine dinucleotide by 22, 51 and 142 percent, reaching those levels within two weeks and holding them for eight. It is the cleanest dose-response in the field, and the trial measured no benefit at all.
The caveat · Paid for and staffed by the seller
Funded by the company that sells the ingredient, with two of the three authors on its staff and the third the inventor of its licensed patents. Eight weeks, in healthy overweight adults. Every number reported is a blood or safety measurement, so the curve describes how much of the pill turns up, not how much it does.