Higher venlafaxine doses brought more withdrawal, in one 2005 dataset
A UK safety review counted withdrawal in 13% of people on 37.5 mg, 11% on 75 mg and 24% on 150 mg, about 92 to 98 people per dose. The US label states the same trend, without numbers.
What the study found
Withdrawal hit 24% at 150 mg of venlafaxine, 13% at the lowest dose
The label says discontinuation symptoms grew more frequent with dose and length of treatment, and gives no number. One set exists: a 2005 UK safety review counted withdrawal in 13% of people on 37.5 mg of venlafaxine, 11% on 75 mg and 24% on 150 mg, about 92 to 98 people per dose.
The caveat · The rise rests on the 150 mg group
The three dose figures are second-hand: a 2022 review copied them from a 2005 UK regulator's report, and the report itself is where the counts live. The middle dose came out lower than the lowest, so the rise rests on the 150 mg group alone. The label gives the trend and no number.
What we don't know
The three dose figures are second-hand: a 2022 review copied them from a 2005 UK regulator's report, and the report itself is where the counts live. The middle dose came out lower than the lowest, so the rise rests on the 150 mg group alone. The label gives the trend and no number.