SubEx
Vitamin D3 (Cholecalciferol)·Support mood·finding 09 of 20
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★★☆Single study — solid evidence, such as one good trial or a large observational dataset, but not replicated at the top tier.

Mood & wellbeing · no significant effect · single study

In low, depressed older adults, a year changed none of nine outcomes

Dutch researchers recruited older adults at once low in vitamin D, depressed and physically limited. A year of 1,200 international units a day doubled their blood levels.

What the study found

The trial that picked the perfect candidates found nothing

Dutch researchers recruited older adults who were at once low in vitamin D, depressed and physically limited, the exact person supplementation is sold to. A year of 1,200 international units of vitamin D3 a day doubled their blood levels and moved none of nine outcomes.

The caveat · 155 people could hide a small effect

Only 155 people took part, so a small real effect could hide inside that. Entry required a level in the insufficient band rather than severe deficiency, which leaves open whether people much further down would respond. What makes the result carry more than its size suggests is that not one of nine outcomes moved in either direction.