Cortisol normally peaks soon after waking and falls away. Across a large pooled body of research, the people whose fall is shallowest had worse mental and physical health.
Every study pooled here watched people rather than assigning anything, so a flat curve may mark illness already underway rather than cause it. The slope was measured differently from study to study, from two saliva samples a day to six or more, which blurs the pooled figure.
