At the doses people actually buy, liver tests looked normal
Among 839 adults taking about 50.3mg of cannabidiol a day for at least 30 days, 9.1% had a raised ALT and 4.0% a raised AST, close to population rates of 8.9% and 4.9%.
What the study found
At about 50mg a day, liver tests came back ordinary
Among 839 US adults who had taken oral cannabidiol for at least 30 days, averaging 50.3mg a day, 9.1% had a raised ALT and 4.0% a raised AST — two blood markers of liver stress — against published population rates of 8.9% and 4.9%. Dose was not linked to the results.
The caveat · Recruited through twelve CBD sellers
There was no control group — the comparison is to historical population figures, not a concurrent placebo arm. Blood was drawn once at 30 days, so a delayed signal would not appear. Participants were recruited through twelve cannabidiol companies, and three of four authors declare industry ties.
What we don't know
The prescription label records liver-enzyme rises that a study of people buying cannabidiol for themselves did not find. Doses differ more than tenfold and so do the people, so the split is about who was studied, not the compound.